CAS 60628-96-8 Bifonazole 99% TC Factory Outlet High quality Bifonazole 99% TC CAS 60628-96-8
For solid formulation, 25kg/drum or bag, 10kg, 1kg, 500g, 250g, 100g, 10g, 5g color alu bag or packing according to customers demand. For liquid formulation, 200L/drum, 20L, 5L, 1L, 500ml, 250ml, 100ml, 50ml, 20ml or packing according to customers demand. Port Tianjin Port Qingdao Port Shanghai Port
Bifonazole represents the first topical broad spectrum antimycotic approved for once daily administration. Its in vitro activity appears equivalent to its structural relative clotrimazole, being effective against dermatophytes, other filamentous fungi, dimorphic fungi and yeasts.
Bifonazole is a topically-active imidazole antifungal compound that has broad spectrum activity in vitro against dermatophytes, molds, yeasts, dimorphic fungi, and some Gram-positive bacteria. It is effective in the treatment of experimental dermatophytic and Candida in animals. Bifonazole is also a potent inhibitor of cytochrome P450 aromatase (Ki = 68 nM, IC50 = 270 nM), which catalyzes the biosynthesis of estrogens from androgens. When applied topically in animals, it demonstrates prolonged retention time in skin with minimal percutaneous absorption, thus minimizing its effect on aromatase.